Article

Discovering Intron Gain Events in Humans through Large-Scale Evolutionary Comparisons

2024-05-04

Abstract excerpt

<h4>ABSTRACT</h4> The rapid growth in the number of sequenced genomes makes it possible to search for the appearance of entirely new introns in the human lineage. In this study, we compared the genomic sequences for 19,120 human protein-coding genes to a collection of 3493 vertebrate genomes, mapping the patterns of intron alignments onto a phylogenetic tree. This mapping allowed us to trace many intron gain even...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e117ae52-7679-59b6-8ff0-817aff1e5360
DOI: 10.1101/2024.05.02.592247

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovering Intron Gain Events in Humans through Large-Scale Evolutionary ComparisonsDOI 10.1101/2024.05.02.592247Read

Comparison of multiple vertebrate genomes reveals the birth and evolution of human exons.Semantic proximity Read

Intronic CNVs cause gene expression variation in human populationsSemantic proximity Read

Evolutionarily conserved genes preferentially accumulate introns.Semantic proximity Read

Inverted Alu repeats in loop-out exon skipping across hominoid evolutionSemantic proximity Read

Human lncRNAs harbor conserved modules embedded in different sequence contextsSemantic proximity Read

Intron-rich ancestors.Semantic proximity Read

Introns encode a vast class of Kink-loop RNAs that autoregulate pre-mRNA splicingSemantic proximity Read

Mammalian introns: when the junk generates molecular diversity.Semantic proximity Read

Predicting <i>Alu</i> exonization in the human genome with a deep learning modelSemantic proximity Read

Human intronless disease associated genes are slowly evolving.Semantic proximity Read

Identification of human-specific transcript variants induced by DNA insertions in the human genome.Semantic proximity Read

Recursive splicing discovery using lariats in total RNA sequencingSemantic proximity Read