Article

Applicability of the mutation-selection balance model to population genetics of heterozygous protein-truncating variants in humans

2018-10-03

Abstract excerpt

The fate of alleles in the human population is believed to be highly affected by the stochastic force of genetic drift. Estimation of the strength of natural selection in humans generally necessitates a careful modeling of drift including complex effects of the population history and structure. Protein truncating variants (PTVs) are expected to evolve under strong purifying selection and to have a relatively high...

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Literature Corpus work: f4539f96-9ab4-5e7c-8735-e4a5e9b3271c
DOI: 10.1101/433961

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