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Article

High burden of private mutations due to explosive human population growth and purifying selection.

BMC genomics - 1 Jan 2014

Gao Feng, Keinan Alon

Abstract excerpt

BACKGROUND: Recent studies have shown that human populations have experienced a complex demographic history, including a recent epoch of rapid population growth that led to an excess in the proportion of rare genetic variants in humans today. This excess can impact the burden of private mutations for each individual, defined here as the proportion of heterozygous variants in each newly sequenced individual that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25056720
DOI: 10.1186/1471-2164-15-S4-S3
PMCID: PMC4083409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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