Article

Modulation of mesenchymal stem cells protection against senescence during long-term expansion by the PI3K/Akt signaling

2023-01-04

Abstract excerpt

<h4>Background: </h4> and Objectives: Therapies using mesenchymal stem cells (MSCs) show immense potential and provide a promising new paradigm for treating previously untreatable diseases. These therapies require direct transplantation of a large number of MSCs obtained by long-term expansion in vitro , resulting in inevitable senescence and a decline in MSC quality, characterized by the appearance of senescence...

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Literature Corpus work: f44dff33-543c-5f8e-b89f-fdd0dff583d0
DOI: 10.21203/rs.3.rs-2414547/v1

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