Article

Racial Disparities in the Genetic Landscape of Acute Myeloid Leukaemia from The Cancer Genome Atlas: Insights from a Bioinformatics Analysis

2023-11-07

Abstract excerpt

Acute myeloid leukaemia (AML) is a heterogeneous disease with complex pathogenesis that affects hematopoietic stem cells. Ethnic and racial disparities have been reported to affect treatment and survival outcomes in AML patients. Here, we analysed clinical and transcriptomic data from The Cancer Genome Atlas (TCGA) to investigate potential differences in the genetic landscape of AML between African and European in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f42feb4d-01fd-569f-93f7-8025f962e71e
DOI: 10.1101/2023.11.06.565754

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Racial Disparities in the Genetic Landscape of Acute Myeloid Leukaemia from The Cancer Genome Atlas: Insights from a Bioinformatics AnalysisDOI 10.1101/2023.11.06.565754Read

Genomic Landscape of Acute Myeloid Leukemia in a mixed African Cohort: A Pilot StudySemantic proximity Read

Insights into the molecular profiles of adult and paediatric acute myeloid leukaemiaSemantic proximity Read

Mapping AML heterogeneity – multi-cohort transcriptomic analysis identifies novel clusters and divergent ex-vivo drug responsesSemantic proximity Read

Broad de-regulated U2AF1 splicing is prognostic and augments leukemic transformation via protein arginine methyltransferase activationSemantic proximity Read

Association of genetic variants and survival in patients with acute myeloid leukemia in rural Appalachia.Semantic proximity Read

Distinct clinical and biological characteristics of acute myeloid leukemia with higher expression of long noncoding RNA KIAA0125Semantic proximity Read

Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targetsSemantic proximity Read

Multiomic profiling identifies predictors of survival in African American patients with acute myeloid leukemia.Semantic proximity Read

Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML Study.Semantic proximity Read

Genetic Mutations in B-Acute Lymphoblastic Leukemia Among African American and European American Children.Semantic proximity Read

Clinical Significance of bZIP In-Frame CEBPA-Mutated Normal Karyotype Acute Myeloid Leukemia.Semantic proximity Read

Gene expression profiling in acute myeloid leukaemia.Semantic proximity Read