Article

Mevalonate kinase inhibits anti-tumor immunity by impairing the tumor cell-intrinsic interferon response in microsatellite instability colorectal cancer

2024-10-08

Abstract excerpt

<title>Abstract</title> <p>Background Inadequate tumor cell-intrinsic interferon response leads to limited efficacy of immune checkpoint blockade (ICB) therapy, such as anti-PD-1. Cholesterol metabolism can sharply regulate anti-tumor immune response. However, the mechanism of cholesterol synthesis affects the tumor cell-intrinsic interferon response in microsatellite instability (MSI) colorectal cancer (CRC) re...

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Literature Corpus work: f409665d-41c7-5603-a194-efb295bb6807
DOI: 10.21203/rs.3.rs-4819905/v1

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