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Article

Variations in candidalysin amino acid sequence influence toxicity and host responses.

mBio - 14 Aug 2024

Wickramasinghe Don N, Lyon Claire M, Lee Sejeong, Hepworth Olivia W, Priest Emily L, Maufrais Corinne, Ryan Adam P, Permal Emmanuelle, Sullivan Derek, McManus Brenda A, Hube Bernhard, Butler Geraldine, d'Enfert Christophe, Naglik Julian R, Richardson Jonathan P

Abstract excerpt

Candida albicans causes millions of mucosal infections in humans annually. Hyphal overgrowth on mucosal surfaces is frequently associated with tissue damage caused by candidalysin, a secreted peptide toxin that destabilizes the plasma membrane of host cells thereby promoting disease and immunopathology. Candidalysin was first identified in C. albicans strain SC5314, but recent investigations have revealed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38953356
DOI: 10.1128/mbio.03351-23
PMCID: PMC11323794

Genes

ECE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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