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Regulation of DNA Methylation in Rheumatoid Arthritis Synoviocytes

31 Dec 2012

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic inflammatory disease in which fibroblast-like synoviocytes (FLS) exhibit an aggressive phenotype. Although the mechanisms responsible are not well defined, epigenetic determinants such as DNA methylation might contribute. DNA methyltransferases (DNMTs) are critical enzymes that establish and maintain DNA methylation. We evaluated whether proinflammatory cytokines might...

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PMID: 23277489
DOI: 10.4049/jimmunol.1202572

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