Article

Alu overexpression leads to increased double-stranded RNA in dermatomyositis

2024-11-04

Abstract excerpt

Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because genes constitute only <2% of our genomes, there is a need to explore the role of the non-coding genome in disease pathogenesis. Our genomes include roughly 1.2 million Alu elements occupying about 10% of the genome and can form double-stranded (ds)RNA capable of triggering MDA5 leading to interferon...

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Literature Corpus work: f38d5ebd-1e38-52db-90db-2ccaf5720f6c
DOI: 10.1101/2024.11.02.24316621

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