Article

Pro-inflammatory polarization and colorectal cancer modulate alternative and intronic polyadenylation in primary human macrophages

2023-02-24

Abstract excerpt

<h4>Summary</h4> Macrophages are essential cells of the immune system that alter their inflammatory profile depending on their microenvironment. Alternative polyadenylation in the 3’UTR (3’UTR-APA) and intronic polyadenylation (IPA) are mechanisms that modulate gene expression, in particular in cancer and activated immune cells. Yet, how polarization and colorectal cancer (CRC) cells microenvironment affect 3’UTR...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f3627b45-c49e-5997-9791-6b6749f0c786
DOI: 10.1101/2023.02.24.529734

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pro-inflammatory polarization and colorectal cancer modulate alternative and intronic polyadenylation in primary human macrophagesDOI 10.1101/2023.02.24.529734Read

CFIm25-Dependent Alternative Polyadenylation in AKT2 mRNA Programs Macrophage PolarizationSemantic proximity Read

Spatiotemporal single cell transcriptomic analysis of human gut macrophages reveals multiple functional and niche-specific subsetsSemantic proximity Read

Macrophage differentiation is marked by increased abundance of the mRNA 3’ end processing machinery, altered poly(A) site usage, and sensitivity to the level of CstF64Semantic proximity Read

Long Non-coding RNAs RN7SK and GAS5 Regulate Macrophage Polarization and Innate Immune Responses.Semantic proximity Read

Integrated analysis of single-cell and bulk RNA-seq unravels the role of macrophage markers ceRNA networks in colorectal cancer’s immune microenvironment and chemotherapy sensitivitySemantic proximity Read

Next-generation sequencing of microRNAs uncovers expression signatures in polarized macrophages.Semantic proximity Read

SPP1+ macrophages: A malignant macrophage subset in the colorectal cancer microenvironment revealed by single-cell sequencingSemantic proximity Read

Alternative Splicing Events in Tumor Immune Infiltration in Colorectal CancerSemantic proximity Read

Alternative polyadenylation mediated by CPSF5 regulates pro-inflammatory gene expressionSemantic proximity Read

The CTCF/LncRNA‐PACERR complex recruits E1A binding protein p300 to induce pro‐tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expressionSemantic proximity Read

Integrated muti-omics analyses and experimental validation reveal the clinical and biological Significances of APBB1IP in Colon CancerSemantic proximity Read

Regulatory Mechanism of lncRNAs in M1/M2 Macrophages Polarization in the Diseases of Different Etiology.Semantic proximity Read