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Article

At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer.

Journal of leukocyte biology - 1 Aug 2014

Hardbower Dana M, Peek Richard M, Wilson Keith T

Abstract excerpt

Helicobacter pylori infection is the strongest known risk factor for the development of gastric cancer. Given that ∼50% of the global population is infected with this pathogen, there is great impetus to elucidate underlying causes that mediate progression from infection to cancer. Recent evidence suggests that H. pylori-induced chronic inflammation and oxidative stress create an environment conducive to DNA...

Topics

DNA Damage
Genetic Predisposition to Disease
Helicobacter Infections
Helicobacter pylori
Humans
Inflammation
Stomach Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 24868089
DOI: 10.1189/jlb.4BT0214-099R
PMCID: PMC4101087

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