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Article

The Pivotal Role of DNA Repair in Infection Mediated-Inflammation and Cancer

11 Apr 2018

Abstract excerpt

Pathogenic and commensal microbes induce various levels of inflammation and metabolic disease in the host. Inflammation caused by infection leads to increased production of reactive oxygen species (ROS) and subsequent oxidative DNA damage. These in turn cause further inflammation and exacerbation of DNA damage, and pose a risk for cancer development. H. pylori-mediated inflammation has been implicated in gastric...

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PMID: 29696001
DOI: 10.3389/fmicb.2018.00663

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