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The stress granule protein G3BP1 binds viral dsRNA and RIG-I to enhance interferon-β response

25 Feb 2019

Abstract excerpt

RIG-I senses viral RNA in the cytosol and initiates host innate immune response by triggering the production of type 1 interferon. A recent RNAi knockdown screen yielded close to hundred host genes whose products affected viral RNA-induced IFN-β production and highlighted the complexity of the antiviral response. The stress granule protein G3BP1, known to arrest mRNA translation, was identified as a regulator of...

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PMID: 30804210
DOI: 10.1074/jbc.ra118.005868

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