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Article

The Regulation of Integrated Stress Response Signaling Pathway on Viral Infection and Viral Antagonism

11 Feb 2022

Abstract excerpt

The integrated stress response (ISR) is an adaptational signaling pathway induced in response to different stimuli, such as accumulation of unfolded and misfolded proteins, hypoxia, amino acid deprivation, viral infection, and ultraviolet light. It has been known that viral infection can activate the ISR, but the role of the ISR during viral infection is still unclear. In some cases, the ISR is a protective...

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PMID: 35222313
DOI: 10.3389/fmicb.2021.814635

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