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Article

GCN5-dependent acetylation of HIV-1 integrase enhances viral integration

12 Mar 2010

Abstract excerpt

BACKGROUND: An essential event during the replication cycle of HIV-1 is the integration of the reverse transcribed viral DNA into the host cellular genome. Our former report revealed that HIV-1 integrase (IN), the enzyme that catalyzes the integration reaction, is positively regulated by acetylation mediated by the histone acetyltransferase (HAT) p300. RESULTS: In this study we demonstrate that another cellular...

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PMID: 20226045
DOI: 10.1186/1742-4690-7-18

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