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A point mutation in HIV-1 integrase redirects proviral integration into centromeric repeats

18 Mar 2022

Abstract excerpt

Retroviruses utilize the viral integrase (IN) protein to integrate a DNA copy of their genome into host chromosomal DNA. HIV-1 integration sites are highly biased towards actively transcribed genes, likely mediated by binding of the IN protein to specific host factors, particularly LEDGF, located at these gene regions. We here report a substantial redirection of integration site distribution induced by a single...

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PMID: 35304442
DOI: 10.1038/s41467-022-29097-8

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