Article

Individualized Interactomes from Pulmonary Arterial Hypertension Cell Biopsies Predict Therapeutic Response

2025-11-15

Abstract excerpt

Pulmonary arterial hypertension (PAH) is characterized by molecular heterogeneity and variable pharmacotherapeutic responses. We used an in silico clinical trial design to test whether transcriptomic data from pulmonary artery endothelial cell biopsies collected during right heart catheterization could be used to build individualized protein-protein interactomes and inform treatment response. Twenty-five PAH part...

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Literature Corpus work: f2fbc258-5632-5483-a990-25ff0b899abf
DOI: 10.1101/2025.11.13.25340200

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