Article

Single-cell transcriptomics reveal diverging pathobiology and opportunities for precision targeting in scleroderma-associated versus idiopathic pulmonary arterial hypertension

2024-10-25

Abstract excerpt

<h4>Introduction</h4> Pulmonary arterial hypertension (PAH) involves progressive cellular and molecular change within the pulmonary vasculature, leading to increased vascular resistance. Current therapies targeting nitric oxide (NO), endothelin, and prostacyclin pathways yield variable treatment responses. Patients with systemic sclerosis-associated PAH (SSc-PAH) often experience worse outcomes than those with id...

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Literature Corpus work: b03fea9b-0fcf-54fb-bb8f-5a1d6fe01606
DOI: 10.1101/2024.10.25.620225

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