Article

The landscape of <i>SNCA</i> transcripts across synucleinopathies: New insights from long reads sequencing analysis

2019-01-18

Abstract excerpt

Dysregulation of alpha-synuclein expression has been implicated in the pathogenesis of synucleinopathies, in particular Parkinson’s Disease (PD) and Dementia with Lewy bodies (DLB). Previous studies have shown that the alternatively spliced isoforms of the SNCA gene are differentially expressed in different parts of the brain for PD and DLB patients. Similarly, SNCA isoforms with skipped exons can have a functiona...

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Literature Corpus work: f2f9474a-6dcc-5a46-843f-576547f10011
DOI: 10.1101/524827

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