Article
Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2017
Tagliafierro Lidia, Glenn Omolara-Chinue, Zamora Madison E, Beach Thomas G, Woltjer Randy L, Lutz Michael W, Chiba-Falek Ornit
Abstract excerpt
INTRODUCTION: The α-synuclein (SNCA) gene has been implicated in the etiology of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). METHODS: A computational analysis of SNCA 3' untranslated region to identify potential microRNA (miRNA) binding sites and quantitative real-time polymerase chain reaction (PCR) to determine their expression in isogenic induced pluripotent stem cell-derived dopaminergic and...
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