Article

Nrh L11R single nucleotide polymorphism, a new prediction biomarker in breast cancer, impacts endoplasmic reticulum-dependent Ca2+ traffic and chemotherapy outcome

2023-01-27

Abstract excerpt

<title>Abstract</title> <p>Overexpression of Bcl-2 proteins such as Bcl2L10, also referred to as Nrh, is associated with resistance to therapy and poor survival in various cancers, including breast cancer, lung cancer and leukemia. The single nucleotide polymorphism (SNP) of BCL2L10 in its BH4 domain at position 11 (BCL2L10 Leu11Arg, rs2231292), corresponding to position 11 in the Nrh open reading frame, is repor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2e65ac5-2f8a-5808-a69f-12c9d33ab72e
DOI: 10.21203/rs.3.rs-2419293/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nrh L11R single nucleotide polymorphism, a new prediction biomarker in breast cancer, impacts endoplasmic reticulum-dependent Ca2+ traffic and chemotherapy outcomeDOI 10.21203/rs.3.rs-2419293/v1Read

Nrh L11R single nucleotide polymorphism, a new prediction biomarker in breast cancer, impacts endoplasmic reticulum-dependent Ca2+ traffic and response to neoadjuvant chemotherapy.Semantic proximity Read

Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connectionSemantic proximity Read

Genomic Mapping Identifies Mutations in RYR2 and AHNAK as Associated with Favorable Outcome in Basal-Like Breast Tumors Expressing PD1/PD-L1Semantic proximity Read

Alterations of the interactome of Bcl-2 proteins in breast cancer at the transcriptional, mutational and structural level.Semantic proximity Read

Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer CellsSemantic proximity Read

A multiOmics approach to identify altered ion channels across breast cancer subtypesSemantic proximity Read

A Case Report: A Rare Casr Mutation Associated with HER2-Positive Breast Cancer.Semantic proximity Read

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.Semantic proximity Read

Role of Sigma-1 Receptor in Calcium Modulation: Possible Involvement in CancerSemantic proximity Read

Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domain.Semantic proximity Read

Polymorphisms in the calcium-sensing receptor gene are associated with clinical outcome of neuroblastoma.Semantic proximity Read

Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines.Semantic proximity Read