Article
Nrh L11R single nucleotide polymorphism, a new prediction biomarker in breast cancer, impacts endoplasmic reticulum-dependent Ca2+ traffic and response to neoadjuvant chemotherapy.
Cell death & disease - 1 Jul 2023
Duong Minh Quang, Gadet Rudy, Treilleux Isabelle, Borel Stéphane, Nougarède Adrien, Marcillat Olivier, Gonzalo Philippe, Mikaelian Ivan, Popgeorgiev Nikolay, Rimokh Ruth, Gillet Germain
Abstract excerpt
Overexpression of Bcl-2 proteins such as Bcl2L10, also referred to as Nrh, is associated with resistance to therapy and poor survival in various cancers, including breast cancer, lung cancer, and leukemia. The single nucleotide polymorphism (SNP) of BCL2L10 in its BH4 domain at position 11 (BCL2L10 Leu11Arg, rs2231292), corresponding to position 11 in the Nrh open reading frame, is reported to lower resistance...
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