Article
Evidence for association of SNPs in ABCB1 and CBR3, but not RAC2, NCF4, SLC28A3 or TOP2B, with chronic cardiotoxicity in a cohort of breast cancer patients treated with anthracyclines.
Pharmacogenomics - 1 Feb 2016
Hertz Daniel L, Caram Megan V, Kidwell Kelley M, Thibert Jacklyn N, Gersch Christina, Seewald Nicholas J, Smerage Jeffrey, Rubenfire Melvyn, Henry N Lynn, Cooney Kathleen A, Leja Monika, Griggs Jennifer J, Rae James M
Abstract excerpt
AIMS: Validation of associations for SNPs in RAC2, NCF4 and SLC28A3, identification of a novel association with a TOP2B SNP and screening 23 SNPs putatively relevant to anthracycline-induced cardiotoxicity. PATIENTS & METHODS: A total of 166 breast cancer patients treated with doxorubicin underwent echocardiogram, including 19 cases with systolic dysfunction (ejection fraction <55%) and 147 controls. Four high...
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