Article

Single-cell sequencing reveals a clonal expansion of pro-inflammatory synovial CD8 T cells expressing tissue homing receptors in psoriatic arthritis

2019-07-16

Abstract excerpt

Psoriatic arthritis (PsA) is a debilitating immune-mediated inflammatory arthritis of unknown pathogenesis commonly affecting patients with skin psoriasis. We used three complementary single cell approaches to study leukocytes from PsA joints. Mass cytometry (CyTOF) demonstrated marked (>3 fold) expansion of memory CD8 T cells in the joints compared to matched blood. Further exploration of the memory CD8 compartme...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2d1dad5-66cc-5479-a5e1-49f6f0e10c0a
DOI: 10.1101/704494

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell sequencing reveals a clonal expansion of pro-inflammatory synovial CD8 T cells expressing tissue homing receptors in psoriatic arthritisDOI 10.1101/704494Read

Linking Skin and Joint Inflammation in Psoriatic Arthritis through Shared CD8 + T Cell ClonesSemantic proximity Read

Clonal sharing of CD8+ T-cells links skin and joint inflammation in psoriatic arthritisSemantic proximity Read

<i>Ex vivo</i> mass cytometry analysis reveals a profound myeloid proinflammatory signature in psoriatic arthritis synovial fluidSemantic proximity Read

CD3+ immune cell endotypes are associated with PsA disease phenotype and response to advanced therapy: an integrated mass cytometry and proteomics cohort study.Semantic proximity Read

Single-cell Landscape of Immune Cells in Blood and Skin in PsoriasisSemantic proximity Read

Combined Single Cell Transcriptome and Surface Epitope Profiling Identifies Potential Biomarkers of Psoriatic Arthritis and Facilitates Diagnosis via Machine LearningSemantic proximity Read

Single cell analysis of spondyloarthritis regulatory T cells identifies distinct synovial gene expression patterns and clonal fatesSemantic proximity Read

Single-cell characterisation of tissue homing CD4+ and CD8+ T cell clones in immune-mediated refractory arthritisSemantic proximity Read

TCR repertoire profiling revealed antigen-driven CD8+ T cell clonal groups shared in synovial fluid of patients with spondyloarthritisSemantic proximity Read

Immune disease dialogue of chemokine-based cell communications as revealed by single-cell RNA sequencing meta-analysisSemantic proximity Read

Integrated single cell and spatial transcriptomics reveal autoreactive differentiated B cells in joints of early rheumatoid arthritisSemantic proximity Read