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Article

CD3+ immune cell endotypes are associated with PsA disease phenotype and response to advanced therapy: an integrated mass cytometry and proteomics cohort study.

Annals of the rheumatic diseases - 1 Mar 2026

Eder Lihi, Dang Steven, Caucheteux Stephane M, Li Xianwei, Thib Sydney, Ganatra Darshini, Ritchlin Christopher, Jurisica Igor, Piguet Vincent, Diao Liqun, Chandran Vinod

Abstract excerpt

OBJECTIVES: This study aims to identify circulating cellular immune cell endotypes in psoriatic arthritis (PsA), assess their association with treatment response, and explore key biological pathways linked to these immune profiles. METHODS: Using mass cytometry, we analysed CD3+ immune cell populations in patients with PsA initiating targeted therapies. Hierarchical clustering identified immune cell endotypes,...

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Antirheumatic Agents
Arthritis, Psoriatic
CD3 Complex
CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Synovial Membrane

T-Lymphocyte Subsets

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Identifiers

PMID: 41206244
DOI: 10.1016/j.ard.2025.10.011

Genes

CD4
C2
C3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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