Article

HSD17B7 is required for the function of sensory hair cells by regulating cholesterol synthesis

2025-07-18

Abstract excerpt

Cholesterol homeostasis is fundamental to cellular function, and its disruption underlies a wide range of human diseases. However, the contribution of cholesterol biosynthesis to auditory physiology remains poorly understood. HSD17B7 (17β-Hydroxysteroid dehydrogenase type 7) catalyzes the conversion of zymosterone to zymosterol, a key step in the post-lanosterol cholesterol biosynthetic pathway. Here, we found tha...

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Literature Corpus work: f2cf94be-6aa6-5ffb-ab08-c774fc2625d8
DOI: 10.1101/2025.07.15.665034

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