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Article

Mutations in 3β-hydroxysteroid-δ8, δ7-isomerase paradoxically benefit epidermal permeability barrier homeostasis in mice.

Experimental dermatology - 1 Mar 2021

Dang Erle, Man George, Lee Dale, Crumrine Debbie A, Mauro Theodora M, Elias Peter M, Man Mao-Qiang

Abstract excerpt

Inherited or acquired blockade of distal steps in the cholesterol synthetic pathway results in ichthyosis, due to reduced cholesterol production and/or the accumulation of toxic metabolic precursors, while inhibition of epidermal cholesterol synthesis compromises epidermal permeability barrier homeostasis. We showed here that 3β-hydroxysteroid-δ8, δ7-isomerase-deficient mice (TD), an analog for CHILD syndrome in...

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Source

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Identifiers

PMID: 33205489
DOI: 10.1111/exd.14236
PMCID: PMC8754084

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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