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Article

Association of GJB2 P.V37I With Sudden Sensorineural Hearing Loss and Endoplasmic Reticulum Stress.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Aug 2026

Lien Kuang-Hsu, Tsai Chia-Lung, Lee Yun-Shien, Chen Tai-Yu, Chao Wei-Chieh, Hu Chih-Yu, Chang Po-Hung, Tsai Chi-Neu

Abstract excerpt

OBJECTIVE: This study aimed to investigate the association between the heterozygous GJB2 p.V37I variant and susceptibility to sudden sensorineural hearing loss (SSNHL), and to explore its potential involvement in endoplasmic reticulum (ER) stress. STUDY DESIGN: Genetic association study with in vitro functional validation. SETTING: Tertiary academic medical center. METHODS: We screened 145 SSNHL patients for 25...

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Identifiers

PMID: 42047511
DOI: 10.1002/ohn.70263
PMCID: PMC13417948

Genes

GJB2
OTOF
SLC26A4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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