Back to search

Article

Erlotinib induces 3D genome rearrangements in lung cancer cells activating tumor suppressor genes through FOXA2-bound Epromoters

2025-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Non-small cell lung cancer (NSCLC) is the most frequent lung cancer (LC). While erlotinib is an epidermal growth factor (EGFR) tyrosine kinase inhibitor (TKI) used in the treatment of NSCLC, it remains unclear how this FDA-approved drug affects the genome. We performed integrative multi-omics studies in human pulmonary carcinoma cells to elucidate the epigenetic mechanisms induced by erlotinib....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
f2c0ff1c-0dbd-5338-90e7-826e8bccb78e
DOI
10.1101/2025.05.13.653883
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Erlotinib induces 3D genome rearrangements in lung cancer cells activating tumor suppressor genes through FOXA2-bound EpromotersDOI 10.1101/2025.05.13.653883
LungCancer3D: A Comprehensive Database for Integrating Lung Cancer Chromatin Architecture with Other Multi-omicsSemantic proximity
The 3D genomic landscape of differential response to EGFR/HER2 inhibition in endocrine-resistant breast cancer cellsSemantic proximity
Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancerSemantic proximity
Oncogenic 3D genome conformations identify novel therapeutic targets in ependymomaSemantic proximity
Chromatin State Dynamics Confers Specific Therapeutic Strategies in Enhancer Subtypes of Colorectal CancerSemantic proximity
L3MBTL1, a polycomb protein, promotes Osimertinib Acquired resistance through Epigenetic Regulation of DNA damage response in lung adenocarcinomaSemantic proximity
SETDB1 fuels the lung cancer phenotype by modulating epigenome, 3D genome organization and chromatin mechanical properties.Semantic proximity
TP63 mediates the generation of tumour-specific chromatin loops that underlie MYC activation in radiation-induced tumorigenesisSemantic proximity
L3MBTL1, a polycomb protein, promotes Osimertinib acquired resistance through epigenetic regulation of DNA damage response in lung adenocarcinomaSemantic proximity
Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cellsSemantic proximity
Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistanceSemantic proximity
EZH2 Inhibition Reshapes 3D Chromatin Architecture to Induce Immunogenic Phenotype in Small Cell Lung CancerSemantic proximity
Select a neighboring publication to make it the new centre.