Article

A type II anti-CD20 monoclonal antibody efficiently depletes CNS B cells in a mouse model of multiple sclerosis

2021-08-05

Abstract excerpt

<title>Abstract</title> <p>BackgroundSuccessful therapy with anti-CD20 monoclonal antibodies (mAbs) has reinforced the key role of B cells in the immunopathology of multiple sclerosis. While treatment with currently available anti-CD20 mAbs results in rapid and robust elimination of vascular B cells, B cells residing within compartments of the central nervous system (CNS) are not well targeted. The aim of this st...

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Literature Corpus work: f2b06448-21b4-56e6-bc8b-512affa9dd35
DOI: 10.21203/rs.3.rs-776877/v1

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