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Article

The regulation and function of CD20: an “enigma” of B-cell biology and targeted therapy

1 Jun 2020

Abstract excerpt

The introduction of anti-CD20 monoclonal antibodies such as rituximab, ofatumumab, or obinutuzumab improved the therapy of B-cell malignancies even though the precise physiological role and regulation of CD20 remains unclear. Furthermore, CD20 expression is highly variable between different B-cell malignancies, patients with the same malignancy, and even between intraclonal subpopulations in an individual...

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PMID: 32482755
DOI: 10.3324/haematol.2019.243543

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