Article

Myelin-reactive B cells exacerbate the severity of CD4 <sup>+</sup> T cell-driven CNS autoimmunity in an IL-23-dependent manner

2019-08-01

Abstract excerpt

Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS) that has traditionally been considered a T cell-mediated disease. However, accumulating evidence points to a crucial role for B cells in disease processes. IgH [MOG] mice possess a transgenic immunoglobulin heavy chain derived from a monoclonal antibody specific to myelin oligodendrocyte glycoprotein (MOG), a key target for auto...

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Literature Corpus work: 513bf53e-684b-5f73-a75a-d9abae3351f1
DOI: 10.1101/721696

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