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CAR-T Cell–Mediated B-Cell Depletion in Central Nervous System Autoimmunity

19 Jan 2023

Abstract excerpt

BACKGROUND AND OBJECTIVES: Anti-CD20 monoclonal antibody (mAb) B-cell depletion is a remarkably successful multiple sclerosis (MS) treatment. Chimeric antigen receptor (CAR)-T cells, which target antigens in a non-major histocompatibility complex (MHC)-restricted manner, can penetrate tissues more thoroughly than mAbs. However, a previous study indicated that anti-CD19 CAR-T cells can paradoxically exacerbate...

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PMID: 36657993
DOI: 10.1212/nxi.0000000000200080

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