Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

B-cell depletion abrogates T cell-mediated demyelination in an antibody-nondependent common marmoset experimental autoimmune encephalomyelitis model.

Journal of neuropathology and experimental neurology - 1 Aug 2012

Jagessar S Anwar, Heijmans Nicole, Bauer Jan, Blezer Erwin L A, Laman Jon D, Hellings Niels, 't Hart Bert A

Abstract excerpt

CD20-positive B-cell depletion is a highly promising treatment for multiple sclerosis (MS), but the mechanisms underlying therapeutic effects are poorly understood. B cells are thought to contribute to MS pathogenesis by producing autoantibodies that amplify demyelination via opsonization of myelin. To analyze autoantibody-nondependent functions of B cells in an animal model of MS, we used a novel T cell-driven...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD20
Share to Callithrix

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD56 Antigen

Share to Demyelinating Diseases

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Lymphocyte Depletion

Share to Myelin-Oligodendrocyte Glycoprotein

Share to Myelin Proteins

Source

Identifiers

PMID: 22805775
DOI: 10.1097/NEN.0b013e3182622691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

B-cell depletion abrogates T cell-mediated demyelination in an antibody-nondependent common marmoset experimental autoimmune encephalomyelitis model.PMID 22805775Read ↗

CAR-T Cell–Mediated B-Cell Depletion in Central Nervous System AutoimmunitySemantic proximity Read ↗

A type II anti-CD20 monoclonal antibody efficiently depletes CNS B cells in a mouse model of multiple sclerosisSemantic proximity Read ↗

Unravelling the T‐cell‐mediated autoimmune attack on CNS myelin in a new primate EAE model induced with MOG<sub>34–56</sub> peptide in incomplete adjuvantSemantic proximity Read ↗

Frontline: Epitope recognition on the myelin/oligodendrocyte glycoprotein differentially influences disease phenotype and antibody effector functions in autoimmune demyelination.Semantic proximity Read ↗

Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitisSemantic proximity Read ↗

B- and T-cell Specific Responses to Vaccination against SARS-CoV-2 in Anti-CD20 Treated Patients with Relapsing-Remitting or Progressive Form of Multiple Sclerosis Reveal Immunosenescent FeaturesSemantic proximity Read ↗

A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple SclerosisSemantic proximity Read ↗

Spontaneous opticospinal encephalomyelitis in a double-transgenic mouse model of autoimmune T cell/B cell cooperationSemantic proximity Read ↗

Anti-CD20 therapy depletes activated myelin-specific CD8 + T cells in multiple sclerosisSemantic proximity Read ↗

Caerulomycin A suppresses the differentiation of naïve T cells and alleviates the symptoms of experimental autoimmune encephalomyelitis.Semantic proximity Read ↗

Anti-CD48 Monoclonal Antibody Attenuates Experimental Autoimmune Encephalomyelitis by Limiting the Number of Pathogenic CD4+ T Cells.Semantic proximity Read ↗

Critical role of activation induced cytidine deaminase in experimental autoimmune encephalomyelitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.