Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interaction of background genetic risk, psychotropic medications, and primary angle closure glaucoma in the UK Biobank

28 Jun 2022

Abstract excerpt

BACKGROUND/AIMS: Psychotropic medications have been reported as a risk factor for angle closure disease. However, the interaction between background genetic risk for primary angle closure glaucoma (PACG) and susceptibility to angle closure disease among psychotropic medication users has not been investigated. Here we demonstrate the utility of a genome-wide polygenic risk score (PRS) in identifying and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glaucoma and retinal disorders
Share to Retinal Development and Disorders
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35763501
DOI: 10.1371/journal.pone.0270530

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of background genetic risk, psychotropic medications, and primary angle closure glaucoma in the UK BiobankPMID 35763501Read ↗

Polygenic risk score-based phenome-wide association for glaucoma and its impact on disease susceptibility in two large biobanks.Semantic proximity Read ↗

Step change in glaucoma polygenic risk score performance enables clinical utility and disease prediction across all major ancestriesSemantic proximity Read ↗

Multi-trait Polygenic Probability Risk Score Enhances Glaucoma Prediction Across AncestriesSemantic proximity Read ↗

Towards modifying the genetic predisposition for glaucoma: An overview of the contribution and interaction of genetic and environmental factors.Semantic proximity Read ↗

Statin use in relation to intraocular pressure, glaucoma, and ocular coherence tomography parameters in the UK BiobankSemantic proximity Read ↗

Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma.Semantic proximity Read ↗

Recall by polygenic risk score in two biobanks supports a genomic approach for glaucoma detectionSemantic proximity Read ↗

Risk Stratification and Clinical Utility of Polygenic Risk Scores in OphthalmologySemantic proximity Read ↗

Glaucoma diagnosis and treatment in the era of precision medicine.Semantic proximity Read ↗

Genome-wide association studies, Polygenic Risk Scores and Mendelian randomisation: an overview of common genetic epidemiology methods for ophthalmic cliniciansSemantic proximity Read ↗

Characteristics of p.Gln368Ter Myocilin Variant and Influence of Polygenic Risk on Glaucoma Penetrance in the UK Biobank.Semantic proximity Read ↗

Glaucoma Polygenic Risk Scores Demonstrate Heterogeneous Performance across 2 Large Multiethnic Cohorts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.