Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension.

doi:10.1167/iovs.14-14803

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Article

Identification of a Novel Mucin Gene HCG22 Associated With Steroid-Induced Ocular Hypertension.

Investigative ophthalmology & visual science - 1 Apr 2015

Jeong Shinwu, Patel Nitin, Edlund Christopher K, Hartiala Jaana, Hazelett Dennis J, Itakura Tatsuo, Wu Pei-Chang, Avery Robert L, Davis Janet L, Flynn Harry W, Lalwani Geeta, Puliafito Carmen A, Wafapoor Hussein, Hijikata Minako, Keicho Naoto, Gao Xiaoyi, Argüeso Pablo, Allayee Hooman, Coetzee Gerhard A, Pletcher Mathew T, Conti David V, Schwartz Stephen G, Eaton Alexander M, Fini M Elizabeth

Abstract excerpt

PURPOSE: The pathophysiology of ocular hypertension (OH) leading to primary open-angle glaucoma shares many features with a secondary form of OH caused by treatment with glucocorticoids, but also exhibits distinct differences. In this study, a pharmacogenomics approach was taken to discover candidate genes for this disorder. METHODS: A genome-wide association study was performed, followed by an independent...

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PMID: 25813999
DOI: 10.1167/iovs.14-14803
PMCID: PMC4416661

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