Article

Sequencing and Imputation in GWAS: Cost-Effective Strategies to Increase Power and Genomic Coverage Across Diverse Populations

2019-02-13

Abstract excerpt

<h4>ABSTRACT</h4> A key aim for current genome-wide association studies (GWAS) is to interrogate the full spectrum of genetic variation underlying human traits, including rare variants, across populations. Deep whole-genome sequencing is the gold standard to capture the full spectrum of genetic variation, but remains prohibitively expensive for large samples. Array genotyping interrogates a sparser set of variant...

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Literature Corpus work: e5a0cf14-24bf-5d61-a4d8-404f24ab0203
DOI: 10.1101/548321

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