Article
Annexin V--heparin oligosaccharide complex suggests heparan sulfate--mediated assembly on cell surfaces.
Structure (London, England : 1993) - 10 Jan 2001
Capila I, Hernáiz M J, Mo Y D, Mealy T R, Campos B, Dedman J R, Linhardt R J, Seaton B A
Abstract excerpt
BACKGROUND: Annexin V, an abundant anticoagulant protein, has been proposed to exert its effects by self-assembling into highly ordered arrays on phospholipid membranes to form a protective anti-thrombotic shield at the cell surface. The protein exhibits very high-affinity calcium-dependent interactions with acidic phospholipid membranes, as well as specific binding to glycosaminoglycans (GAGs) such as heparin...
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