Article

TDP-43 aberrant phosphorylation in Amyotrophic Lateral Sclerosis (ALS) and in Niemann-Pick type C (NPC) disease

2021-01-01

Abstract excerpt

In 2006, human Trans-Active Regulator DNA Binding Protein (TDP-43) was identified as the major ubiquitinated component of inclusion bodies in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD), two important neurodegenerative diseases in the human population. In ALS/FTLD, TDP-43 that is normally present in the nucleus, is found aggregated in the cytoplasm where it is also abnormally p...

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Literature Corpus work: f2766f1a-2f9b-5f6e-8c75-0aae0570045c
DOI: 10.21954/ou.ro.0001295a

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