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Article

TDP-43 is a culprit in human neurodegeneration, and not just an innocent bystander.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 May 2008

Banks Gareth T, Kuta Anna, Isaacs Adrian M, Fisher Elizabeth M C

Abstract excerpt

In 2006 the protein TDP-43 was identified as the major ubiquitinated component deposited in the inclusion bodies found in two human neurodegenerative diseases, amyotrophic lateral sclerosis and frontotemporal lobar degeneration. The pathogenesis of both disorders is unclear, although they are related by having some overlap of symptoms and now by the shared histopathology of TDP-43 deposition. Now, in 2008,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18592312
DOI: 10.1007/s00335-008-9117-x
PMCID: PMC2515551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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