Article

Aryl hydrocarbon receptor–kynurenine axis promotes oncogenic activity in BCP-ALL

2022-04-05

Abstract excerpt

B-cell precursor acute lymphoblastic leukemia (BCP-ALL), the most common childhood cancer, originates from lymphoid precursor cells in bone marrow committed to the B-cell lineage. Environmental factors and genetic abnormalities disturb the normal maturation of these precursor cells, promoting the formation of leukemia cells and suppressing normal hematopoiesis. The underlying mechanisms of progression are unclear,...

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Literature Corpus work: f261bdc3-8d47-5a76-a811-a592bb0a052d
DOI: 10.21203/rs.3.rs-1501266/v1

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