Environmental and genetic risk factors for childhood leukemia: appraising the evidence.

Abstract excerpt

Childhood leukemia is the most common cause of malignancy under the age of 15, representing an annual incidence rate of 43 cases per million in the United States. Confirmed clinical and epidemiologic associations explain less than 10% of disease incidence, leaving 90% of cases with an unclear etiology. To effectively study leukemia in children, one must recognize that this disease has a multifactorial causal...

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