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AhR and STAT3: A Dangerous Duo in Chemical Carcinogenesis

18 Mar 2025

Abstract excerpt

Human chemical carcinogenesis is a multistage process where chemicals or their metabolites cause irreversible changes in normal cell physiology, eventually leading to uncontrolled proliferation, transforming a normal cell into a cancerous one. Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription factor that regulates cell proliferation, differentiation, apoptosis,...

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PMID: 40141386
DOI: 10.3390/ijms26062744

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