Article

Siderophore-Mediated Conveyance of Antibacterial-Antisense Oligomers

2023-10-30

Abstract excerpt

Antibacterial resistance is a major threat for human health. There is a need for new antibacterials to stay ahead of constantly-evolving resistant bacteria. Antibiotic antisense oligomers hold promise as powerful next-generation antibiotics, but issues with their delivery hamper their applicability. Here, we exploit the siderophore-mediated iron uptake pathway to efficiently transport antisense oligomers into bact...

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Literature Corpus work: f232edab-35a0-5ef9-9d8c-5eeb32416c12
DOI: 10.1101/2023.10.30.564798

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