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Antibiotic-Polymer Self-Assembled Nanocomplex to Reverse Phenotypic Resistance of Bacteria toward Last-Resort Antibiotic Colistin.

ACS nano - 22 Aug 2023

Zhao Huimin, Zhong Lan-Lan, Yang Chuan, Tang Ning, He Yanwei, He Wan, Zhao Zihan, Wu Changbu, Yuan Peiyan, Yang Yi Yan, Tian Guo-Bao, Ding Xin

Abstract excerpt

Colistin is the last-resort antibiotic to treat multidrug-resistant (MDR) Gram-negative bacterial infections that are untreatable by other clinically available antibiotics. However, the recently merged plasmid-borne gene mobilized colistin resistance (mcr) leads to modification of the colistin target (i.e., bacterial membrane), greatly compromising the therapy outcome of colistin. To address this unmet clinical...

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PMID: 37534992
DOI: 10.1021/acsnano.3c00981

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