Article
Iron transport-mediated drug delivery using mixed-ligand siderophore-beta-lactam conjugates.
Chemistry & biology - 1 Dec 1996
Ghosh A, Ghosh M, Niu C, Malouin F, Moellmann U, Miller M J
Abstract excerpt
BACKGROUND: Assimilation of iron is essential for microbial growth. Most microbes synthesize and excrete low molecular weight iron chelators called siderophores to sequester and deliver iron by active transport processes. Specific outer membrane proteins recognize, bind and initiate transport of...
Topics
- Anti-Bacterial Agents
- Bacteria
- Bacterial Outer Membrane Proteins
- Biological Transport
- Escherichia coli
- Iron
- Molecular Structure
- Mutation
- Pharmaceutical Preparations
- Porins
- Receptors, Cell Surface
- Siderophores