Article

Stable Cell Clones Harboring Self-Replicating SARS-CoV-2 RNAs for Drug Screen

2021-11-08

Abstract excerpt

<h4>ABSTRACT</h4> The development of antivirals against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been hampered by the lack of efficient cell-based replication systems that are amenable to high-throughput screens in biosafety level 2 laboratories. Here we report that stable cell clones harboring autonomously replicating SARS-CoV-2 RNAs without S, M, E genes can be efficiently derived from t...

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Literature Corpus work: 83abd159-6c91-5af9-b82c-5af54c8b4c3c
DOI: 10.1101/2021.11.04.467291

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