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A transient brain endothelial translatome response to endotoxin is associated with mild cognitive changes post-shock in young mice

2024-03-06

Abstract excerpt

Sepsis-associated encephalopathy (SAE) is a common manifestation in septic patients that is associated with increased risk of long-term cognitive impairment. SAE is driven, at least in part, by brain endothelial dysfunction in response to systemic cytokine signaling. However, the mechanisms driving SAE and its consequences remain largely unknown. Here, we performed translating ribosome affinity purification and RN...

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Literature Corpus work
f1f650cf-b241-52b6-b61b-4348729e700f
DOI
10.1101/2024.03.03.583191
Open publication

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A transient brain endothelial translatome response to endotoxin is associated with mild cognitive changes post-shock in young miceDOI 10.1101/2024.03.03.583191
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