Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Creating a "pro-survival" phenotype through epigenetic modulation.

Surgery - 1 Sept 2012

Li Yongqing, Liu Baoling, Gu Xuesong, Kochanek Ashley R, Fukudome Eugene Y, Liu Zhengcai, Zhao Ting, Chong Wei, Zhao Yili, Zhang Dainan, Libermann Towia A, Alam Hasan B

Abstract excerpt

BACKGROUND: We demonstrated recently that treatment with suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, improved survival in a rodent model of lipopolysaccharide (LPS)-induced endotoxic shock. The precise mechanisms, however, have not been well-defined. The aim of this study was to investigate the impact of SAHA treatment on gene expression profiles at an early stage of shock. METHODS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to C-Reactive Protein
Share to Epigenomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxamic Acids

Share to Lipopolysaccharides

Share to Nerve Tissue Proteins

Share to Shock, Septic

Share to Transcription, Genetic

Share to Vorinostat

Source

Open in PubMed Open full text

Identifiers

PMID: 22938904
DOI: 10.1016/j.surg.2012.06.036
PMCID: PMC3782099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Creating a "pro-survival" phenotype through epigenetic modulation.PMID 22938904Read ↗

Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock.Semantic proximity Read ↗

Creating a "Prosurvival Phenotype" Through Histone Deacetylase Inhibition: Past, Present, and Future.Semantic proximity Read ↗

Epigenetic coordination of acute systemic inflammation: potential therapeutic targetsSemantic proximity Read ↗

Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic PathwaysSemantic proximity Read ↗

SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome.Semantic proximity Read ↗

DUALISTIC SAHA DOSE-DEPENDENT EFFECTS ON GLIAL-INFLAMMATORY RESPONSESemantic proximity Read ↗

Novel Regulators of the Systemic Response to LipopolysaccharideSemantic proximity Read ↗

Enriched Environment Causes Epigenetic Alterations in the Hippocampus and Improve Long-term Cognitive Function Sepsis-InducedSemantic proximity Read ↗

Epigenetic regulation of immune cell functions during post-septic immunosuppressionSemantic proximity Read ↗

Acute Systemic Inflammatory Response Alters Transcription Profile of Genes Related to Immune Response and Ca2+ Homeostasis in Hippocampus; Relevance to Neurodegenerative DisordersSemantic proximity Read ↗

NAD+ dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65.Semantic proximity Read ↗

Neuroprotection by the histone deacetylase inhibitor trichostatin A in a model of lipopolysaccharide-sensitised neonatal hypoxic-ischaemic brain injurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.