Article

Brain endothelial PTPRO drives LPS-induced metabolic reprogramming and neuroinflammation in Sepsis-associated encephalopathy

2026-02-23

Abstract excerpt

<title>Abstract</title> <p>Background Sepsis-associated encephalopathy (SAE) is characterized by profound neuroinflammation and blood–brain barrier (BBB) disruption, yet the molecular mechanisms linking endothelial metabolic reprogramming to neuroinflammatory responses remain poorly defined. Protein tyrosine phosphatase receptor type O (PTPRO) has been implicated in endothelial signaling; however, its role in me...

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Literature Corpus work: 0f374541-8668-5970-a2cf-14bf3a459ba4
DOI: 10.21203/rs.3.rs-8847490/v1

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